Journal Article

Invasive Pneumococcal Infections in Canadian Children, 1991–1998: Implications for New Vaccination Strategies

David Scheifele, Scott Halperin, Louise Pelletier and James Talbot

in Clinical Infectious Diseases

Published on behalf of Infectious Diseases Society of America

Volume 31, issue 1, pages 58-64
Published in print July 2000 | ISSN: 1058-4838
Published online July 2000 | e-ISSN: 1537-6591 | DOI: http://dx.doi.org/10.1086/313923
Invasive Pneumococcal Infections in Canadian Children, 1991–1998: Implications for New Vaccination Strategies

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We reviewed 2040 consecutive cases of invasive pneumococcal infection that were seen at 11 pediatric centers across Canada during 1991–1998 to determine if such infections could be prevented by new conjugate vaccines. Isolates from 1528 cases were serotyped. Most cases (61.5%) occurred in patients aged >2 years. Underlying medical conditions were present in 23.2% of case patients. Serotypes in the 7-valent conjugate vaccine matched isolates as follows: 85.8% of tested isolates from children aged 6 months to 5 years, but significantly fewer isolates in younger and older children; 72.9% of isolates from non-healthy children, but 83.9% of isolates from previously healthy children; and 95.4% of isolates with high-level penicillin resistance, but only 72.7% of those with intermediate-level resistance. Significant natural variation in the proportion of isolates matching 7-valent vaccines occurred from year to year and among centers. New conjugate vaccines have great potential but their effectiveness and limitations require ongoing study.

Journal Article.  4459 words.  Illustrated.

Subjects: Infectious Diseases ; Immunology ; Public Health and Epidemiology ; Microbiology

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