Journal Article

Antibiotic Susceptibility Profiles for Group B Streptococci Isolated from Neonates, 1995–1998

Feng-Ying C. Lin, Parvin H. Azimi, Leonard E. Weisman, Joseph B. Philips, Joan Regan, Penny Clark, George G. Rhoads, John Clemens, James Troendle, Ele Pratt, Ruth A. Brenner and Vee Gill

in Clinical Infectious Diseases

Published on behalf of Infectious Diseases Society of America

Volume 31, issue 1, pages 76-79
Published in print July 2000 | ISSN: 1058-4838
Published online July 2000 | e-ISSN: 1537-6591 | DOI: http://dx.doi.org/10.1086/313936
Antibiotic Susceptibility Profiles for Group B Streptococci Isolated from Neonates, 1995–1998

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Antibiotic susceptibility profiles were analyzed for 119 invasive and 227 colonizing strains of group B streptococci isolated from neonates at 6 US academic centers. All strains were susceptible to penicillin, vancomycin, chloramphenicol, and cefotaxime. The rate of resistance to erythromycin was 20.2% and to clindamycin was 6.9%. Resistance to erythromycin increased in 1997. Type V strains were more resistant to erythromycin than were type Ia (P = .003) and type Ib (P = .004) strains and were more resistant to clindamycin than were type Ia (P < .001), type Ib (P = .01), and type III (P = .001) strains. Resistance rates varied with geographic region: in California, there were high rates of resistance to erythromycin and clindamycin (32% and 12%, respectively), and low rates in Florida (8.5% and 2.1%, respectively). Penicillin continues to be the drug of choice for treatment of group B streptococcus infection. For women who are penicillin intolerant, however, the selection of an alternative antibiotic should be guided by contemporary resistance patterns observed in that region.

Journal Article.  2835 words.  Illustrated.

Subjects: Infectious Diseases ; Immunology ; Public Health and Epidemiology ; Microbiology

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