Journal Article

<i>Pseudallescheria boydii</i> Brain Abscess Successfully Treated with Voriconazole and Surgical Drainage: Case Report and Literature Review of Central Nervous System Pseudallescheriasis

Mark A. Nesky, E. Colin McDougal and James E. Peacock

in Clinical Infectious Diseases

Published on behalf of Infectious Diseases Society of America

Volume 31, issue 3, pages 673-677
Published in print September 2000 | ISSN: 1058-4838
Published online September 2000 | e-ISSN: 1537-6591 | DOI: http://dx.doi.org/10.1086/314042
Pseudallescheria boydii Brain Abscess Successfully Treated with Voriconazole and Surgical Drainage: Case Report and Literature Review of Central Nervous System Pseudallescheriasis

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Pseudallescheria boydii and its asexual form, Scedosporium apiospermum, are ubiquitous, saprophytic fungi that commonly cause cutaneous infection. However, in certain circumstances, P. boydii can also cause invasive disease, which can involve the central nervous system (CNS). When the CNS becomes involved, treatment is difficult, therapeutic options are limited, and the prognosis is poor. We report a case of Pseudallescheria brain abscess successfully treated with surgical drainage and systemic voriconazole, the first such case to be described in the literature. We also review previously reported cases of CNS pseudallescheriasis and evaluate therapeutic options.

Journal Article.  3398 words.  Illustrated.

Subjects: Infectious Diseases ; Immunology ; Public Health and Epidemiology ; Microbiology

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