Journal Article

Role of Animal Models in Understanding Intravesical Therapy with Bacille Calmette-Guérin

Timothy L. Ratliff

in Clinical Infectious Diseases

Published on behalf of Infectious Diseases Society of America

Volume 31, issue Supplement_3, pages S106-S108
Published in print September 2000 | ISSN: 1058-4838
Published online September 2000 | e-ISSN: 1537-6591 | DOI: http://dx.doi.org/10.1086/314065
Role of Animal Models in Understanding Intravesical Therapy with Bacille Calmette-Guérin

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Animal models provide a vehicle for understanding basic biological questions. Through the use of animal models, adequate control of experimental design is possible so that rigorous experiments can be performed to test a hypothesis. In the case of testing therapeutic mechanisms, it is important to select a model that is most analogous to the clinical setting so that observations can be readily transferred to clinical studies for validation. In mechanistic studies of Mycobacterium bovis strain (bacille Calmette-Guérin) therapy for bladder cancer, the orthotopic animal model most closely mimics the clinical treatment of bladder cancer.

Journal Article.  1668 words. 

Subjects: Infectious Diseases ; Immunology ; Public Health and Epidemiology ; Microbiology

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