Journal Article

Carboxy Terminal Variants of Epstein-Barr Virus-Encoded Latent Membrane Protein 1 during Long-Term Human Immunodeficiency Virus Infection: Reliable Markers for Individual Strain Identification

Christoph Berger, Debbie van Baarle, Marie José Kersten, Michèl R. Klein, A. Samer Al-Homsi, Brenda Dunn, Cathy McQuain, Rien van Oers and Hans Knecht

in The Journal of Infectious Diseases

Published on behalf of Infectious Diseases Society of America

Volume 179, issue 1, pages 240-244
Published in print January 1999 | ISSN: 0022-1899
Published online January 1999 | e-ISSN: 1537-6613 | DOI: http://dx.doi.org/10.1086/314547
Carboxy Terminal Variants of Epstein-Barr Virus-Encoded Latent Membrane Protein 1 during Long-Term Human Immunodeficiency Virus Infection: Reliable Markers for Individual Strain Identification

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To assess the frequency and molecular polymorphism of malignancy-associated latent membrane protein 1 (LMP1) variants in human immunodeficiency virus type 1 (HIV-1) infection, 94 B-lymphoblastoid cell lines spontaneously derived from peripheral blood mononuclear cells (PBMC) and 30 PBMC samples at seroconversion and later (mean, 55 months) were analyzed by longitudinal comparative sequence analysis in 8 patients progressing to non-Hodgkin's lymphoma (AIDS-NHL), 7 patients to opportunistic infections, and 2 patients with long-term asymptomatic HIV-1 infection. The sequence polymorphism in the C-terminus of LMP1 was characteristic for strains harbored by individual patients, with high fidelity for strain identification. In 14 of the 17 patients, two different but characteristic LMP1 variants were identified. At HIV seroconversion in 8 of 15 patients, a 30-bp deletion (LMP1Δ) was present. Though serial analysis revealed a shift to LMP1Δ in some individuals, statistical analysis of the cohort does not support the hypothesis that accumulation of LMP1Δ variants in PBMC accounts for their observed high incidence in AIDS-NHL.

Journal Article.  2523 words.  Illustrated.

Subjects: Infectious Diseases ; Immunology ; Public Health and Epidemiology ; Microbiology

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