Journal Article

Restricted Low-Level Human Antibody Responses against Epstein-Barr Virus (EBV)—Encoded Latent Membrane Protein 1 in a Subgroup of Patients with EBV-Associated Diseases

Pauline Meij, Marcel B. H. J. Vervoort, Jamil Aarbiou, Paul van Dissel, Arjen Brink, Elisabeth Bloemena, Chris J. L. M. Meijer and Jaap M. Middeldorp

in The Journal of Infectious Diseases

Published on behalf of Infectious Diseases Society of America

Volume 179, issue 5, pages 1108-1115
Published in print May 1999 | ISSN: 0022-1899
Published online May 1999 | e-ISSN: 1537-6613 | DOI: http://dx.doi.org/10.1086/314704
Restricted Low-Level Human Antibody Responses against Epstein-Barr Virus (EBV)—Encoded Latent Membrane Protein 1 in a Subgroup of Patients with EBV-Associated Diseases

More Like This

Show all results sharing these subjects:

  • Infectious Diseases
  • Immunology
  • Public Health and Epidemiology
  • Microbiology

GO

Show Summary Details

Preview

Human antibody responses to latent membrane protein 1 (LMP1) in patients with Epstein-Barr virus (EBV)—related disease syndromes were analyzed in detail. Only by immunoblot analysis with purified recombinant LMP1 and by IFA on recombinant LMP1-expressing insect cells could human antibodies directed against LMP1 be detected. Low serum levels of LMP1-directed antibodies could be detected in 3 of 8 EBV-positive Hodgkin's disease patients, 3 of 40 nasopharyngeal carcinoma patients, 2 of 23 Burkitt's lymphoma patients, and 1 of 27 non-Burkitt's lymphoma patients. No LMP1-directed antibodies could be detected in healthy EBV carriers, infectious mononucleosis patients, or patients with chronic EBV disease. All sera contained significant levels of EBV antibodies directed against the immunodominant EBV proteins and peptides. From this study, it can be concluded that LMP1 is a protein with a very low immunogenicity for the humoral immune response in humans.

Journal Article.  5848 words.  Illustrated.

Subjects: Infectious Diseases ; Immunology ; Public Health and Epidemiology ; Microbiology

Full text: subscription required

How to subscribe Recommend to my Librarian

Users without a subscription are not able to see the full content. Please, subscribe or login to access all content.