Journal Article

Aspergillosis among People Infected with Human Immunodeficiency Virus: Incidence and Survival

Kimberly J. Holding, Mark S. Dworkin, Pei-Chun T. Wan, Debra L. Hanson, Ruth M. Klevens, Jeffrey L. Jones and Patrick S. Sullivan

in Clinical Infectious Diseases

Published on behalf of Infectious Diseases Society of America

Volume 31, issue 5, pages 1253-1257
Published in print November 2000 | ISSN: 1058-4838
Published online November 2000 | e-ISSN: 1537-6591 | DOI: http://dx.doi.org/10.1086/317452
Aspergillosis among People Infected with Human Immunodeficiency Virus: Incidence and Survival

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Aspergillosis is a life-threatening fungal infection in immunocompromised people, including people infected with human immunodeficiency virus (HIV). We determined the incidence of aspergillosis among HIV-infected people and survival after aspergillosis diagnosis by use of a national HIV surveillance database. Among 35,252 HIV-infected patients, the incidence of aspergillosis was 3.5 cases per 1000 person-years (p-y; 95% confidence interval [CI], 3.0–4.0 per 1000 p-y). Incidence was higher among people aged ⩾35 years (4.1 per 1000 p-y, 95% CI, 3.5–4.8), among people with CD4 counts of 50–99 cells/mm3 (5.1 per 1000 p-y, 95% CI, 2.8–7.3), or CD4 counts of <50 cells/mm3 (10.2 per 1000 p-y, 95% CI, 8.0–12.2), versus people with CD4 counts of >200 cells/mm3, people with ⩾1 acquired immune deficiency syndrome-defining opportunistic illness (8.6 per 1000 p-y, 95% CI, 7.4–9.9), and people who were prescribed at least one medication associated with neutropenia (27.7 per 1000 p-y, 95% CI, 21.0–34.3). Median survival time after diagnosis of aspergillosis was 3 months, and 26% survived for ⩾1 year. These findings suggest that aspergillosis is uncommon, occurs especially among severely immunosuppressed or leukopenic HIV-infected people, and is associated with poor survival.

Journal Article.  2212 words.  Illustrated.

Subjects: Infectious Diseases ; Immunology ; Public Health and Epidemiology ; Microbiology

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