Journal Article

Decline in Antibiotic Enzyme Activity of Neutrophils Is a Prognostic Factor for Infections in Patients with Myelodysplastic Syndrome

Yoshikazu Ito, Yoshikazu Kawanishi, Nahoko Shoji and Kazuma Ohyashiki

in Clinical Infectious Diseases

Published on behalf of Infectious Diseases Society of America

Volume 31, issue 5, pages 1292-1295
Published in print November 2000 | ISSN: 1058-4838
Published online November 2000 | e-ISSN: 1537-6591 | DOI: http://dx.doi.org/10.1086/317470
Decline in Antibiotic Enzyme Activity of Neutrophils Is a Prognostic Factor for Infections in Patients with Myelodysplastic Syndrome

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We used flow cytometry to measure the activities of cathepsin G and elastase. The activity of elastase in neutrophils from patients with myelodysplastic syndrome (MDS) was significantly lower than that in neutrophils from the control group (P < .001). Patients with low elastase activity were significantly susceptible to infection (P < .05). Our study suggests that analyzing antibacterial enzymes is useful in evaluating the prognosis of patients with MDS.

Journal Article.  2729 words.  Illustrated.

Subjects: Infectious Diseases ; Immunology ; Public Health and Epidemiology ; Microbiology

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