Journal Article

Nonrespiratory <i>Stenotrophomonas maltophilia</i> Infection at a Children's Hospital

Carlos A. Sattler, Edward O. Mason and Sheldon L. Kaplan

in Clinical Infectious Diseases

Published on behalf of Infectious Diseases Society of America

Volume 31, issue 6, pages 1321-1330
Published in print December 2000 | ISSN: 1058-4838
Published online December 2000 | e-ISSN: 1537-6591 | DOI:
Nonrespiratory Stenotrophomonas maltophilia Infection at a Children's Hospital

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To describe Stenotrophomonas maltophilia infection in children, we reviewed the medical records of patients with isolates from nonrespiratory sites and identified 85 episodes, 51 (60%) of which represented true infection. Forty-two episodes (82.4%) were hospital acquired. Commonly associated with S. maltophilia infection were underlying illness (in 90.2% of cases), previous hospitalizations (in 78.7%), previous antibiotic exposure (in 78.4%), and the presence of a central venous catheter (in 76.5%). Polymicrobial isolates were obtained in 70.6% of episodes; Pseudomonas aeruginosa and Acinetobacter species were the most common coisolates. Bloodstream infection was the most frequent clinical syndrome (32 [63%] of 51 episodes). Fever or sepsis occurred in 22 (69%) and shock in 10 (31%) of 32 episodes. Infection at other sites was less severe. The most active antibiotics in vitro were trimethoprim-sulfamethoxazole and ticarcillin-clavulanate. The overall and attributable mortality rates were 12.5% and 6.3%, respectively. S. maltophilia appears to be an important cause of nosocomially acquired bacteremia in children. The significance in children of isolation from other sites is less clear.

Journal Article.  8621 words.  Illustrated.

Subjects: Infectious Diseases ; Immunology ; Public Health and Epidemiology ; Microbiology

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