Journal Article

Acute Renal Failure: Unusual complication of Epstein-Barr Virus—Induced Infectious Mononucleosis

Paul S. Lei, Amy Lowichik, Wain Allen and Teri Jo Mauch

in Clinical Infectious Diseases

Published on behalf of Infectious Diseases Society of America

Volume 31, issue 6, pages 1519-1524
Published in print December 2000 | ISSN: 1058-4838
Published online December 2000 | e-ISSN: 1537-6591 | DOI: http://dx.doi.org/10.1086/317497
Acute Renal Failure: Unusual complication of Epstein-Barr Virus—Induced Infectious Mononucleosis

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A 17-year-old boy with juvenile rheumatoid arthritis presented with jaundice, confusion, hemolytic anemia, thrombocytopenia, and acute renal failure secondary to titer-confirmed acute Epstein-Barr virus (EBV). Renal biopsy specimen revealed interstitial nephritis with an inflammatory infiltrate composed of cytotoxic/suppressor T cells, and interstitial mononuclear cell nuclei expressed EBV encoded RNA-1 (EBER-1) mRNA. Methylprednisolone treatment resulted in rapid improvement.

Journal Article.  3293 words.  Illustrated.

Subjects: Infectious Diseases ; Immunology ; Public Health and Epidemiology ; Microbiology

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