Journal Article

Choosing a Route of Administration for Quadrivalent Meningococcal Polysaccharide Vaccine: Intramuscular versus Subcutaneous

Frederick L. Ruben, James E. Froeschle, Carlton Meschievitz, Kevin Chen, James George, Mary Kathryn Reeves-Hoché, Patricia Pietrobon, Mike Bybel, William C. Livingood and Lynn Woodhouse

in Clinical Infectious Diseases

Published on behalf of Infectious Diseases Society of America

Volume 32, issue 1, pages 170-172
Published in print January 2001 | ISSN: 1058-4838
Published online January 2001 | e-ISSN: 1537-6591 | DOI: http://dx.doi.org/10.1086/317553
Choosing a Route of Administration for Quadrivalent Meningococcal Polysaccharide Vaccine: Intramuscular versus Subcutaneous

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A clinical trial was conducted to compare intramuscular (im) with subcutaneous (sc) routes for administration of quadrivalent meningococcal polysaccharide vaccine in 141 adults. Safety assessment showed the im route had reduced erythema (P < .01) and reduced headache on days 1 and 2 (P < .05). Serological testing for serum bactericidal antibody titers against capsular groups A and C did not detect significant differences.

Journal Article.  1348 words.  Illustrated.

Subjects: Infectious Diseases ; Immunology ; Public Health and Epidemiology ; Microbiology

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