Journal Article

Short-Course of Oral Miltefosine for Treatment of Visceral Leishmaniasis

Shyam Sundar, Anand Makharia, Deepak K. More, Gaurav Agrawal, Andreas Voss, Christina Fischer, Peter Bachmann and Henry W. Murray

in Clinical Infectious Diseases

Published on behalf of Infectious Diseases Society of America

Volume 31, issue 4, pages 1110-1113
Published in print October 2000 | ISSN: 1058-4838
Published online October 2000 | e-ISSN: 1537-6591 | DOI: http://dx.doi.org/10.1086/318122
Short-Course of Oral Miltefosine for Treatment of Visceral Leishmaniasis

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A total of 54 Indian patients with visceral leishmaniasis were treated with oral miltefosine, 50 mg given twice daily, for 14 days (18 patients; group A), 21 days (18; group B), or 28 days (18; group C). Cure was achieved in 89% of group A, 100% of group B, and 100% of group C. Adverse reactions were self-limited and primarily mild. The 21-day miltefosine regimen combines high-level efficacy, convenient dosing, and a relatively short duration.

Journal Article.  2759 words.  Illustrated.

Subjects: Infectious Diseases ; Immunology ; Public Health and Epidemiology ; Microbiology

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