Journal Article

Human Herpesvirus 6 Infection after Autologous or Allogeneic Stem Cell Transplantation: A Single-Center Prospective Longitudinal Study of 92 Patients

B. M. Imbert-Marcille, X. W. Tang, D. Lepelletier, B. Besse, P. Moreau, S. Billaudel and N. Milpied

in Clinical Infectious Diseases

Published on behalf of Infectious Diseases Society of America

Volume 31, issue 4, pages 881-886
Published in print October 2000 | ISSN: 1058-4838
Published online October 2000 | e-ISSN: 1537-6591 | DOI: http://dx.doi.org/10.1086/318142
Human Herpesvirus 6 Infection after Autologous or Allogeneic Stem Cell Transplantation: A Single-Center Prospective Longitudinal Study of 92 Patients

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To determine the incidence and clinical relevance of active human herpesvirus 6 (HHV-6) infection, 92 consecutive unselected recipients of autologous or allogeneic stem cell grafts were investigated in a prospective longitudinal study. Active infection was assessed by the presence of viral deoxyribonucleic acid (DNA) in 846 peripheral blood mononuclear cell specimens and 115 plasma specimens, by means of a specially developed polymerase chain reaction designed to avoid detection of latent genome. The incidence of HHV-6 infection observed was 42.5%, irrespective of the type or source of graft, and infection was significantly associated with partial (P = .002) or total myelosuppression (P = .01) and fever (P < .000001). Infusion of bone marrow as the source of graft, reactivation occurring before platelet or neutrophil engraftment, and presence of HHV-6 DNA in plasma were identified as risk factors for symptomatic HHV-6 infection (P < .002).

Journal Article.  4475 words.  Illustrated.

Subjects: Infectious Diseases ; Immunology ; Public Health and Epidemiology ; Microbiology

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