Journal Article

Patients with Active Tuberculosis Have Increased Expression of HIV Coreceptors CXCR4 and CCR5 on CD4<sup>+</sup> T Cells

Nicole P. Juffermans, Peter Speelman, Annelies Verbon, Jan Veenstra, Cornelis Jie, Sander J. H. van Deventer and Tom van der Poll

in Clinical Infectious Diseases

Published on behalf of Infectious Diseases Society of America

Volume 32, issue 4, pages 650-652
Published in print February 2001 | ISSN: 1058-4838
Published online February 2001 | e-ISSN: 1537-6591 | DOI: http://dx.doi.org/10.1086/318701
Patients with Active Tuberculosis Have Increased Expression of HIV Coreceptors CXCR4 and CCR5 on CD4+ T Cells

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Expression of human immunodeficiency virus (HIV) coreceptors CXCR4 and CCR5 was found to be elevated on CD4+ T cells (1) in blood samples obtained from patients with tuberculosis and (2) in blood samples obtained from healthy subjects and stimulated with mycobacterial lipoarabinomannan in vitro. These data suggest that the increase in HIV viremia that occurs in association with tuberculosis may result from up-regulation of CXCR4 and CCR5 on CD4+ T cells, thereby causing acceleration of HIV infection.

Journal Article.  1667 words.  Illustrated.

Subjects: Infectious Diseases ; Immunology ; Public Health and Epidemiology ; Microbiology

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