Journal Article

Transepithelial Intestinal Excretion of Ciprofloxacin in Humans

Jacob Ramon, Menachem Ben-Haim, Moshe Shabtai and Ethan Rubinstein

in Clinical Infectious Diseases

Published on behalf of Infectious Diseases Society of America

Volume 32, issue 5, pages 822-823
Published in print March 2001 | ISSN: 1058-4838
Published online March 2001 | e-ISSN: 1537-6591 | DOI: https://dx.doi.org/10.1086/319206
Transepithelial Intestinal Excretion of Ciprofloxacin in Humans

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The excretion of ciprofloxacin in the small bowel was studied in 40 patients undergoing bowel surgery. Ciprofloxacin (200 mg) was administered iv, and intestinal samples were collected over a 120-min period. In ileal loops ciprofloxacin concentrations reached a peak of 4.0 mg/L, whereas in caecal fluid samples, concentrations were <0.16 mg/L. Ciprofloxacin administered directly into the ileal and caecal loops did not result in measurable blood levels for 2 h. The results confirm that ciprofloxacin is selectively excreted into the small bowel.

Journal Article.  1101 words.  Illustrated.

Subjects: Infectious Diseases ; Immunology ; Public Health and Epidemiology ; Microbiology

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