Journal Article

Prediction of Gram-Negative Bacteremia in Patients with Cancer and Febrile Neutropenia by Means of Interleukin-8 Levels in Serum: Targeting Empirical Monotherapy versus Combination Therapy

Winfried V. Kern, Monika Heiss and Gerald Steinbach

in Clinical Infectious Diseases

Published on behalf of Infectious Diseases Society of America

Volume 32, issue 5, pages 832-835
Published in print March 2001 | ISSN: 1058-4838
Published online March 2001 | e-ISSN: 1537-6591 | DOI: http://dx.doi.org/10.1086/319207
Prediction of Gram-Negative Bacteremia in Patients with Cancer and Febrile Neutropenia by Means of Interleukin-8 Levels in Serum: Targeting Empirical Monotherapy versus Combination Therapy

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In a prospective observational study of 133 neutropenic episodes, interleukin (IL)-8 serum levels >2000 pg/mL at the onset of fever had a sensitivity of 53% and a specificity of 97% as a predictor of gram-negative bacteremia (GNB; positive predictive value, 73%; negative predictive value, 94%). The rates of early death differed significantly between patients with high and those with low IL-8 levels (3/11 vs. 1/122; P < .01). Serum IL-8 levels at the onset of fever define a low-risk subgroup of patients who can safely be treated with monotherapy.

Journal Article.  2730 words.  Illustrated.

Subjects: Infectious Diseases ; Immunology ; Public Health and Epidemiology ; Microbiology

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