Journal Article

Recurrences of Cytomegalovirus Retinitis in a Human Immunodeficiency Virus-Infected Patient, Despite Potent Antiretroviral Therapy and Apparent Immune Reconstitution

Steven C. Johnson, Constance A. Benson, David W. Johnson and Adriana Weinberg

in Clinical Infectious Diseases

Published on behalf of Infectious Diseases Society of America

Volume 32, issue 5, pages 815-819
Published in print March 2001 | ISSN: 1058-4838
Published online March 2001 | e-ISSN: 1537-6591 | DOI: http://dx.doi.org/10.1086/319219
Recurrences of Cytomegalovirus Retinitis in a Human Immunodeficiency Virus-Infected Patient, Despite Potent Antiretroviral Therapy and Apparent Immune Reconstitution

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We describe a 42-year-old man with human immunodeficiency virus infection who developed multiple recurrences of cytomegalovirus (CMV) retinitis despite receiving highly active antiretroviral therapy and having apparent immune reconstitution as evidenced by CD4+ T lymphocyte counts of >200 cells/mm3. Laboratory investigation during one recurrence of retinitis confirmed that there was active CMV replication in the plasma and vitreous fluid. In addition, lymphoproliferative responses to CMV antigens were absent despite evidence of reactivity to Candida antigen and pokeweed mitogen. The clinical significance of this case and of other recently reported cases is discussed.

Journal Article.  2871 words.  Illustrated.

Subjects: Infectious Diseases ; Immunology ; Public Health and Epidemiology ; Microbiology

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