Journal Article

Treatment of Chronic Hepatitis C with Amantadine Hydrochloride in Patients Who Had Not Responded to Previous Treatment with Interferon-α and/or Ribavirin

Vincent Di Martino, Hamza Boudjema, Thierry Delacour, Alain Cazier, Catherine Caron, Pierre Coutarel, Patrice Dumouchel and Jean-François Cadranel

in Clinical Infectious Diseases

Published on behalf of Infectious Diseases Society of America

Volume 32, issue 5, pages 830-831
Published in print March 2001 | ISSN: 1058-4838
Published online March 2001 | e-ISSN: 1537-6591 | DOI: http://dx.doi.org/10.1086/319220
Treatment of Chronic Hepatitis C with Amantadine Hydrochloride in Patients Who Had Not Responded to Previous Treatment with Interferon-α and/or Ribavirin

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Seven women and 3 men infected with hepatitis C virus, all of whom had failed to respond to therapy with either IFN-α or IFN and ribavirin, were treated with 200 mg/day of amantadine hydrochloride for 12 months. We found a significant decrease of serum ALT activity without any decrease in virus load. These results suggest that amantadine hydrochloride should not be used as monotherapy for patients who do not respond to treatment with IFN-α and/or ribavirin.

Journal Article.  1307 words.  Illustrated.

Subjects: Infectious Diseases ; Immunology ; Public Health and Epidemiology ; Microbiology

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