Journal Article

Erroneously Low or Undetectable Plasma Human Immunodeficiency Virus Type 1 (HIV-1) Ribonucleic Acid Load, Determined by Polymerase Chain Reaction, in West African and American Patients with Non-B Subtype HIV-1 Infection

Elizabeth R. Jenny-Avital and Sara T. Beatrice

in Clinical Infectious Diseases

Published on behalf of Infectious Diseases Society of America

Volume 32, issue 8, pages 1227-1230
Published in print April 2001 | ISSN: 1058-4838
Published online April 2001 | e-ISSN: 1537-6591 | DOI: http://dx.doi.org/10.1086/319752
Erroneously Low or Undetectable Plasma Human Immunodeficiency Virus Type 1 (HIV-1) Ribonucleic Acid Load, Determined by Polymerase Chain Reaction, in West African and American Patients with Non-B Subtype HIV-1 Infection

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The polymerase chain reaction (PCR) assay for plasma human immunodeficiency virus type 1 (HIV-1) ribonucleic acid (RNA) inadequately quantitates virus load for some non-B HIV-1 subtypes because of genetic diversity in the gag region targeted by the PCR primers. Unexpectedly low or undetectable plasma HIV-1 RNA findings by PCR were a clue to non-B HIV-1 infections in patients in whom plasma HIV-1 RNA was found to be substantially higher when determined by a branched-chain deoxyribonucleic acid assay.

Journal Article.  2241 words.  Illustrated.

Subjects: Infectious Diseases ; Immunology ; Public Health and Epidemiology ; Microbiology

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