Journal Article

Inhibition of Methicillin-Resistant <i>Staphylococcus aureus</i> Colonization of Oral Cavities in Newborns by Viridans Group Streptococci

Yoshio Uehara, Ken Kikuchi, Tomohiko Nakamura, Hidenori Nakama, Kazunaga Agematsu, Yoshiyuki Kawakami, Nobuhiro Maruchi and Kyoichi Totsuka

in Clinical Infectious Diseases

Published on behalf of Infectious Diseases Society of America

Volume 32, issue 10, pages 1399-1407
Published in print May 2001 | ISSN: 1058-4838
Published online May 2001 | e-ISSN: 1537-6591 | DOI: http://dx.doi.org/10.1086/320147
Inhibition of Methicillin-Resistant Staphylococcus aureus Colonization of Oral Cavities in Newborns by Viridans Group Streptococci

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We investigated the role of viridans group streptococci in the prevention of colonization with methicillin-resistant Staphylococcus aureus (MRSA) in neonatal intensive care units. During a 26-month period at a children's hospital, 207 (49.9%) of 415 newborns were colonized with MRSA by the time of discharge. Two groups of newborns with matching durations of hospitalization were compared with regard to the prevalence of future colonization with MRSA: group 1 (103 patients) did not acquire colonization with viridans group streptococci and group 2 (63 patients) did acquire colonization with viridans group streptococci at birth or by 1 to 2 weeks (age, ⩽11 days). The rate of colonization among patients in group 2 (9.5%) was significantly lower than that among patients in group 1 (44.7%; P < .001). No significant difference in patient characteristics (e.g., birth weight, diseases) was observed. These results indicate that viridans group streptococci, as bacteria that formerly occupied the oral cavities in newborns, may inhibit later colonization with MRSA.

Journal Article.  4644 words.  Illustrated.

Subjects: Infectious Diseases ; Immunology ; Public Health and Epidemiology ; Microbiology

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