Journal Article

H<sub>2</sub>O<sub>2</sub> Produced by Viridans Group Streptococci May Contribute to Inhibition of Methicillin-Resistant <i>Staphylococcus aureus</i> Colonization of Oral Cavities in Newborns

Yoshio Uehara, Ken Kikuchi, Tomohiko Nakamura, Hidenori Nakama, Kazunaga Agematsu, Yoshiyuki Kawakami, Nobuhiro Maruchi and Kyoichi Totsuka

in Clinical Infectious Diseases

Published on behalf of Infectious Diseases Society of America

Volume 32, issue 10, pages 1408-1413
Published in print May 2001 | ISSN: 1058-4838
Published online May 2001 | e-ISSN: 1537-6591 | DOI: http://dx.doi.org/10.1086/320179
H2O2 Produced by Viridans Group Streptococci May Contribute to Inhibition of Methicillin-Resistant Staphylococcus aureus Colonization of Oral Cavities in Newborns

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In an accompanying report, we showed that viridans group streptococci may prevent methicillin-resistant Staphylococcus aureus (MRSA) colonization of the oral cavities of newborns. In the present study, we investigated the mechanism of prevention in vitro. Most viridans group streptococci had bacteriocin-like activity and killed MRSA, Burkholderia cepacia, Enterobacter aerogenes, and Pseudomonas aeruginosa; however, Escherichia coli, Enterobacter cloacae, and Candida albicans were resistant. The activity was induced only by H2O2-secreting strains and was inhibited by horseradish peroxidase or catalase in a dose-dependent manner. The mean concentration of H2O2 produced by 18 strains of viridans group streptococci (1 × 108 cfu in 200 µL of culture medium ± standard deviation was 1.24 ± 0.60 mmol. Viridans group streptococci inhibited MRSA growth in saliva as well as in culture media. These results indicate that H2O2 produced by viridans group streptococci may inhibit MRSA colonization of oral cavities in newborns.

Journal Article.  3362 words.  Illustrated.

Subjects: Infectious Diseases ; Immunology ; Public Health and Epidemiology ; Microbiology

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