Journal Article

<i>pap</i> Genotype and P Fimbrial Expression in <i>Escherichia coli</i> Causing Bacteremic and Nonbacteremic Febrile Urinary Tract Infection

Gisela Otto, Mattias Magnusson, Majlis Svensson, JeanHenrik Braconier and Catharina Svanborg

in Clinical Infectious Diseases

Published on behalf of Infectious Diseases Society of America

Volume 32, issue 11, pages 1523-1531
Published in print June 2001 | ISSN: 1058-4838
Published online June 2001 | e-ISSN: 1537-6591 | DOI: http://dx.doi.org/10.1086/320511
pap Genotype and P Fimbrial Expression in Escherichia coli Causing Bacteremic and Nonbacteremic Febrile Urinary Tract Infection

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Escherichia coli strains from patients with febrile urinary tract infections (n = 73) were examined for pap genotype and P fimbrial expression in relation to bacteremia and patients' background variables. Most isolates were pap+ by DNA hybridization (n = 51), and 36 were papGIA2+ and 18 prsGJ96+ by polymerase chain reaction. The pap and pap G genotypes of the infecting strain were shown to vary with host compromise, sex, and age. Bacteremia in noncompromised patients was caused by papGIA2+ strains, but compromised hosts carried a mixture of papGIA2+, prsGJ96+, and pap strains. Women of all ages were infected with papGIA2+ strains. Infected men carried prsGJ96+ or pap strains and were older, and most had compromising conditions. papGIA2+ strains predominated among patients with medical illness, whereas prsGJ96+ strains predominated among patients with urinary tract abnormalities. These findings emphasize the strong influence of host factors on the selection of E. coli strains causing febrile urinary tract infections.

Journal Article.  4210 words.  Illustrated.

Subjects: Infectious Diseases ; Immunology ; Public Health and Epidemiology ; Microbiology

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