Journal Article

Short-Course Therapy for Right-Side Endocarditis Due to <i>Staphylococcus aureus</i> in Drug Abusers: Cloxacillin versus Glycopeptides in Combination with Gentamicin

Jesús Fortún, Enrique Navas, Jesús Martínez-Beltrán, J. Pérez-Molina, Pilar Martín-Dávila, Antonio Guerrero and Santiago Moreno

in Clinical Infectious Diseases

Published on behalf of Infectious Diseases Society of America

Volume 33, issue 1, pages 120-125
Published in print July 2001 | ISSN: 1058-4838
Published online July 2001 | e-ISSN: 1537-6591 | DOI: http://dx.doi.org/10.1086/320869
Short-Course Therapy for Right-Side Endocarditis Due to Staphylococcus aureus in Drug Abusers: Cloxacillin versus Glycopeptides in Combination with Gentamicin

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A prospective, randomized clinical trial among drug abusers was conducted to assess the efficacy and safety of a short course of a combination of a glycopeptide (vancomycin or teicoplanin) and gentamicin compared with a combination of cloxacillin and gentamicin for treatment of right-side endocarditis caused by Staphylococcus aureus. Therapeutic success was significantly more frequent with cloxacillin than with a glycopeptide. No adverse effects were noted among patients in the cloxacillin group. A 14-day course of vancomycin or teicoplanin plus gentamicin is ineffective in this instance because it is associated with a high rate of clinical and microbiological failure.

Journal Article.  3102 words.  Illustrated.

Subjects: Infectious Diseases ; Immunology ; Public Health and Epidemiology ; Microbiology

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