Journal Article

Diagnosis and Management of Posttransplant Lymphoproliferative Disorder in Solid-Organ Transplant Recipients

Jutta K. Preiksaitis and Susan Keay

in Clinical Infectious Diseases

Published on behalf of Infectious Diseases Society of America

Volume 33, issue Supplement_1, pages S38-S46
Published in print July 2001 | ISSN: 1058-4838
Published online July 2001 | e-ISSN: 1537-6591 | DOI: https://dx.doi.org/10.1086/320903
Diagnosis and Management of Posttransplant Lymphoproliferative Disorder in Solid-Organ Transplant Recipients

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The Epstein-Barr virus (EBV) has a pivotal pathophysiologic role in the development of most lymphoproliferative disorders that occur after solid-organ transplantation. The term “EBV-associated posttransplant lymphoproliferative disorder” (PTLD) includes all clinical syndromes of EBV-associated lymphoproliferation, ranging from uncomplicated posttransplant infectious mononucleosis to true malignancies that contain clonal chromosomal abnormalities. PTLDs are historically associated with a high mortality rate in patients who have a monoclonal form of the disorder. Recently described approaches to pathology, diagnosis, treatment, and preventive strategies of PTLD, however, have the potential to improve outcome.

Journal Article.  7542 words.  Illustrated.

Subjects: Infectious Diseases ; Immunology ; Public Health and Epidemiology ; Microbiology

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