Journal Article

Role of Pharmacokinetics and Pharmacodynamics: Does the Dose Matter?

Alasdair P. MacGowan

in Clinical Infectious Diseases

Published on behalf of Infectious Diseases Society of America

Volume 33, issue Supplement_3, pages S238-S239
Published in print September 2001 | ISSN: 1058-4838
Published online September 2001 | e-ISSN: 1537-6591 | DOI: http://dx.doi.org/10.1086/321855
Role of Pharmacokinetics and Pharmacodynamics: Does the Dose Matter?

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Antibiotic dose is important in determining serum area-under-the-curve (AUC) and peak serum concentration (Cmax), as well as the time the serum concentration remains over the pathogen minimum inhibitory concentration (T>MIC). However, dose is not the sole determinant of these factors; they are modified by absorption, clearance, and frequency of dosing. It is difficult to relate dose to clinical outcome in humans, but pharmacodynamic parameters (AUC/MIC, Cmax/MIC, or T>MIC) have been related to clinical and bacteriological efficacy or emergence of resistance to aminoglycosides, fluoroquinolones, glycopeptides, and β-lactams.

Journal Article.  1264 words. 

Subjects: Infectious Diseases ; Immunology ; Public Health and Epidemiology ; Microbiology

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