Journal Article

Value of Patient Self-Report and Plasma Human Immunodeficiency Virus Protease Inhibitor Level as Markers of Adherence to Antiretroviral Therapy: Relationship to Virologic Response

Michel Duong, Lionel Piroth, Gilles Peytavin, Fabien Forte, Evelyne Kohli, Michèle Grappin, Marielle Buisson, Pascal Chavanet and Henri Portier

in Clinical Infectious Diseases

Published on behalf of Infectious Diseases Society of America

Volume 33, issue 3, pages 386-392
Published in print August 2001 | ISSN: 1058-4838
Published online August 2001 | e-ISSN: 1537-6591 | DOI: http://dx.doi.org/10.1086/321876
Value of Patient Self-Report and Plasma Human Immunodeficiency Virus Protease Inhibitor Level as Markers of Adherence to Antiretroviral Therapy: Relationship to Virologic Response

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Three methods of adherence to antiretroviral therapy were evaluated for 149 patients infected with human immunodeficiency virus (HIV): plasma level of protease inhibitors (PIs), patient self-report, and routine biological parameters associated with the use of some antiretroviral drugs. Adherence to therapy was estimated from a score calculated from answers to a self-administered questionnaire and on the basis of measurement of relevant plasma and blood levels. Of the 149 patients, 112 had a virologic response, and 122 had adequate trough PI levels. Plasma PI levels and virologic outcome were significantly correlated (P < .0001). The adherence score was significantly correlated with virologic response (P < .001). Macrocytosis was significantly associated with virologic response in the patients treated with zidovudine or stavudine (P = .006). PI level was the higher significant predictor of virologic response (P = .0003). Self-reported adherence (P = .01) and macrocytosis (P = .05) were also independently associated with antiretroviral efficacy.

Journal Article.  4623 words.  Illustrated.

Subjects: Infectious Diseases ; Immunology ; Public Health and Epidemiology ; Microbiology

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