Journal Article

Fatal Submassive Hepatic Necrosis Associated with Tyrosine-Methionine-Aspartate-Aspartate-Motif Mutation of Hepatitis B Virus after Long-Term Lamivudine Therapy

Jin Wook Kim, Hyo-Suk Lee, Gwang Hoon Woo, Jung-Hwan Yoon, Ja-June Jang, Je Geun Chi and Chung Yong Kim

in Clinical Infectious Diseases

Published on behalf of Infectious Diseases Society of America

Volume 33, issue 3, pages 403-405
Published in print August 2001 | ISSN: 1058-4838
Published online August 2001 | e-ISSN: 1537-6591 | DOI: http://dx.doi.org/10.1086/321879
Fatal Submassive Hepatic Necrosis Associated with Tyrosine-Methionine-Aspartate-Aspartate-Motif Mutation of Hepatitis B Virus after Long-Term Lamivudine Therapy

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We present a case of infection with lamivudine-resistant mutant hepatitis B virus (HBV) that fatally exacerbated hepatitis following the emergence of HBV with mutations in the tyrosine-methionine-aspartate-aspartate (YMDD) motif in an immunocompetent patient who was receiving long-term lamivudine therapy. Restriction fragment length polymorphism analysis showed that the YMDD-motif mutant was the predominant form of circulating HBV at the time of the fatal exacerbation, and a necropsy specimen of the liver revealed submassive hepatic necrosis without steatosis.

Journal Article.  1552 words.  Illustrated.

Subjects: Infectious Diseases ; Immunology ; Public Health and Epidemiology ; Microbiology

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