Journal Article

Association of Tuberculin Sensitivity in Dutch Adults with History of Travel to Areas of with a High Incidence of Tuberculosis

Frank G. J. Cobelens, Henk van Deutekom, Inez W. E. Draayer-Jansen, Ank C. H. M. Schepp-Beelen, Paul J. H. J. van Gerven, Rob P. M. van Kessel and Marlies E. A. Mensen

in Clinical Infectious Diseases

Published on behalf of Infectious Diseases Society of America

Volume 33, issue 3, pages 300-304
Published in print August 2001 | ISSN: 1058-4838
Published online August 2001 | e-ISSN: 1537-6591 | DOI: http://dx.doi.org/10.1086/321882
Association of Tuberculin Sensitivity in Dutch Adults with History of Travel to Areas of with a High Incidence of Tuberculosis

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International travel may be a source of introduction of tuberculosis into low-incidence countries. We assessed whether, in The Netherlands, sensitivity to tuberculin was associated with a history of travel to countries with a high incidence of tuberculosis. Immunocompetent adults with no history of Bacille Calmette-Guérin vaccination or sensitivity to tuberculin were skin-tested simultaneously with 1-tuberculin unit (TU) purified protein derivative (PPD) of Mycobacterium tuberculosis and 1-TU sensitin of Mycobacterium scrofulaceum. Tuberculin sensitivity was defined as a reaction to PPD of ⩾10 mm that was ⩾3 mm larger than the reaction to M. scrofulaceum sensitin. Tuberculin sensitivity was found in 7 (0.7%) of 1014 participants (95% confidence interval [CI], 0.3%–1.4%); it was independently associated with a cumulative history of >3-months' travel to high-incidence areas (odds ratio, 6.0; 95% CI, 1.2–31.2; P = .016) and increased in association with total duration of travel (P = .02). Travel to high-incidence areas increases the risk of tuberculin sensitivity and, consequently, of latent tuberculous infection. In countries with a low incidence of tuberculosis, cases of infection acquired during travel may account for a substantial proportion of new infections in the resident population.

Journal Article.  3130 words.  Illustrated.

Subjects: Infectious Diseases ; Immunology ; Public Health and Epidemiology ; Microbiology

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