Journal Article

Sabin Monovalent Oral Polio Vaccines: Review of Past Experiences and Their Potential Use after Polio Eradication

Victor M. Cáceres and Roland W. Sutter

in Clinical Infectious Diseases

Published on behalf of Infectious Diseases Society of America

Volume 33, issue 4, pages 531-541
Published in print August 2001 | ISSN: 1058-4838
Published online August 2001 | e-ISSN: 1537-6591 | DOI: http://dx.doi.org/10.1086/321905
Sabin Monovalent Oral Polio Vaccines: Review of Past Experiences and Their Potential Use after Polio Eradication

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After global eradication of polio is achieved, there will be a need for stockpiles of vaccine to combat potential outbreaks of poliomyelitis caused by (1) unforeseen release of polioviruses, (2) continued circulation of vaccine-derived strains, or (3) prolonged replication of polioviruses in immunodeficient persons. We conducted a review of the literature to document the immunogenicity and safety of monovalent Sabin vaccines, considered ideal candidates for these situations. The National Library of Medicine archives were searched for the keywords “polio,” “monovalent,” and “vaccine.” Seroconversion rates for monovalent Sabin type 1 ranged from 53% to 100% (median, 95%); for type 2, 77%–100% (median, 93%); and for type 3, 52%–100% (median, 85%). The risk of vaccine-associated poliomyelitis per million persons vaccinated ranged from .05 to 0.99 (type 1), 0–0.65 (type 2), and 1.18–8.91 (type 3). Single-dose monovalent Sabin vaccines are highly immunogenic and safe and should be considered for stockpiles of vaccine to provide an effective response to potential outbreaks of poliomyelitis in the post-eradication period.

Journal Article.  7023 words.  Illustrated.

Subjects: Infectious Diseases ; Immunology ; Public Health and Epidemiology ; Microbiology

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