Journal Article

Influence of Human Immunodeficiency Virus Infection on the Course of Hepatitis C Virus Infection: A Meta-Analysis

C. S. Graham, L. R. Baden, E. Yu, J. M. Mrus, J. Carnie, T. Heeren and M. J. Koziel

in Clinical Infectious Diseases

Published on behalf of Infectious Diseases Society of America

Volume 33, issue 4, pages 562-569
Published in print August 2001 | ISSN: 1058-4838
Published online August 2001 | e-ISSN: 1537-6591 | DOI: http://dx.doi.org/10.1086/321909
Influence of Human Immunodeficiency Virus Infection on the Course of Hepatitis C Virus Infection: A Meta-Analysis

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Studies have shown that rates of liver disease are higher in persons who are coinfected with human immunodeficiency virus (HIV) and hepatitis C virus (HCV) than they are in persons with HCV alone, but estimates of risk vary widely and are based on data for dissimilar patient populations. We performed a meta-analysis to quantify the effect of HIV coinfection on progressive liver disease in persons with HCV. Eight studies were identified that included outcomes of histological cirrhosis or decompensated liver disease. These studies yielded a combined adjusted relative risk (RR) of 2.92 (95% confidence interval [CI], 1.70–5.01). Of note, studies that examined decompensated liver disease had a combined RR of 6.14 (95% CI, 2.86–13.20), whereas studies that examined histological cirrhosis had a pooled RR of 2.07 (95% CI, 1.40–3.07). There is a significantly elevated RR of severe liver disease in persons who are coinfected with HIV and HCV. This has important implications for timely diagnosis and consideration of treatment in coinfected persons.

Journal Article.  4969 words.  Illustrated.

Subjects: Infectious Diseases ; Immunology ; Public Health and Epidemiology ; Microbiology

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