Journal Article

Arthus Reaction to Recombinant Hepatitis B Virus Vaccine

Hervey Froehlich and Rajeev Verma

in Clinical Infectious Diseases

Published on behalf of Infectious Diseases Society of America

Volume 33, issue 6, pages 906-908
Published in print September 2001 | ISSN: 1058-4838
Published online September 2001 | e-ISSN: 1537-6591 | DOI: https://dx.doi.org/10.1086/322585
Arthus Reaction to Recombinant Hepatitis B Virus Vaccine

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A severe, local, inflammatory, late-phase reaction accompanied by skin necrosis occurred after an infant was given an intramuscular injection of recombinant hepatitis B virus vaccine. The clinical course and appearance of the rash were typical of an Arthus reaction. Although not identical to this case, prior reported cases of complement-mediated reactions occurring after hepatitis B virus infection or vaccination provide theoretical support for this diagnosis.

Journal Article.  2050 words.  Illustrated.

Subjects: Infectious Diseases ; Immunology ; Public Health and Epidemiology ; Microbiology

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