Journal Article

Lack of Seroconversion in a Health Care Worker after Polymerase Chain Reaction—Documented Acute Hepatitis C Resulting from a Needlestick Injury

Patrice Morand, Nadine Dutertre, Hélène Minazzi, Jean Burnichon, Martine Pernollet, Maryline Baud, Jean-Pierre Zarski and Jean-Marie Seigneurin

in Clinical Infectious Diseases

Published on behalf of Infectious Diseases Society of America

Volume 33, issue 5, pages 727-729
Published in print September 2001 | ISSN: 1058-4838
Published online September 2001 | e-ISSN: 1537-6591 | DOI: http://dx.doi.org/10.1086/322619
Lack of Seroconversion in a Health Care Worker after Polymerase Chain Reaction—Documented Acute Hepatitis C Resulting from a Needlestick Injury

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We present a case of documented acute hepatitis C that occurred in a health care worker who sustained a needlestick injury while caring for an individual who was infected with both hepatitis C virus (HCV) and human immunodeficiency virus (HIV). According to the findings of third-generation serological assays performed during a follow-up of >1 year, the health care worker, who was treated with interferon-α (during weeks 2–6) and ribavirin (during weeks 5–9), did not develop antibodies against HCV, in spite of documentation of an HCV-specific T cell response.

Journal Article.  1791 words.  Illustrated.

Subjects: Infectious Diseases ; Immunology ; Public Health and Epidemiology ; Microbiology

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