Journal Article

Salivary Cytomegalovirus (CMV) Shedding, Glycoprotein B Genotype Distribution, and CMV Disease in Human Immunodeficiency Virus-Seropositive Patients

N. Fidouh-Houhou, X. Duval, F. Bissuel, V. Bourbonneux, P. Flandre, J. L. Ecobichon, M. C. Jordan, J. L. Vildé, F. Brun-Vézinet and C. Leport

in Clinical Infectious Diseases

Published on behalf of Infectious Diseases Society of America

Volume 33, issue 8, pages 1406-1411
Published in print October 2001 | ISSN: 1058-4838
Published online October 2001 | e-ISSN: 1537-6591 | DOI: http://dx.doi.org/10.1086/322630
Salivary Cytomegalovirus (CMV) Shedding, Glycoprotein B Genotype Distribution, and CMV Disease in Human Immunodeficiency Virus-Seropositive Patients

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To assess the frequency of shedding of cytomegalovirus (CMV) in saliva, the distribution of CMV glycoprotein B (gB) genotypes, and the occurrence of CMV diseases, we screened 98 human immunodeficiency virus (HIV)-seropositive patients without CMV disease. CMV was detected by culture more frequently in saliva (45 [46%] of 98 patients) than in blood (7 [7.5%] of 93) and was associated with CD4 cell counts <100 cells/mm3 (P = .013). CMV in the saliva of 37 patients was successfully genotyped. Three patients (8%) were infected by a gB1 strain, 26 (70%) by a gB2 strain, 2 (5.5%) by a gB3 strain, 1 (3%) by a gB4 strain, and 5 (13.5%) by mixed gB strains. Thirteen patients developed CMV disease after a mean period of 143 ± 112 days; at inclusion, 9 (69%) had salivary CMV shedding and 2 had CMV viremia. CMV salivary shedding (P = .043), low CD4+ cell count (P = .041), and CMV viremia (P = .011) were associated with occurrence of CMV disease.

Journal Article.  3374 words.  Illustrated.

Subjects: Infectious Diseases ; Immunology ; Public Health and Epidemiology ; Microbiology

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