Journal Article

Mass Vaccination of Children with Pertussis Toxoid—Decreased Incidence in Both Vaccinated and Nonvaccinated Persons

John Taranger, Birger Trollfors, Elisabet Bergfors, Nina Knutsson, Valter Sundh, Teresa Lagergård, Lena Lind-Brandberg, Gunilla Zackrisson, Jo White, Helen Cicirello, Joan Fusco and John B. Robbins

in Clinical Infectious Diseases

Published on behalf of Infectious Diseases Society of America

Volume 33, issue 7, pages 1004-1009
Published in print October 2001 | ISSN: 1058-4838
Published online October 2001 | e-ISSN: 1537-6591 | DOI: http://dx.doi.org/10.1086/322639
Mass Vaccination of Children with Pertussis Toxoid—Decreased Incidence in Both Vaccinated and Nonvaccinated Persons

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During 1979–1995, there was no vaccination against pertussis in Sweden. With the aim of studying the epidemiology and transmission of pertussis, mass vaccination with pertussis toxoid of children born during the 1990s was instituted in the Göteborg area (population, 778,597) in 1995. Infants were offered 3 doses of pertussis toxoid combined with diphtheria and tetanus toxoids. Children aged ≥1 year were offered 3 doses of pertussis toxoid alone. From June 1995 through February 1999, 167,810 doses of pertussis toxoid were given to 61,219 children born during the 1990s (56% received 3 doses). The number of Bordetella pertussis isolates per year declined from 1214 (1993–1995) to 64 (January 1997 through June 1999; P < .0001), and hospitalizations due to pertussis declined from 62 to 5 (P < .0001). Significant decreases in B. pertussis isolates and hospitalizations occurred in all age groups, including adults and nonvaccinated infants. Thus, mass vaccination of children with pertussis toxoid decreases spread of B. pertussis in the population.

Journal Article.  4514 words.  Illustrated.

Subjects: Infectious Diseases ; Immunology ; Public Health and Epidemiology ; Microbiology

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