Journal Article

Evolution of Antifungal Susceptibility among <i>Candida</i> Species Isolates Recovered from Human Immunodeficiency Virus—Infected Women Receiving Fluconazole Prophylaxis

Jose A. Vazquez, Grace Peng, Jack D. Sobel, Lynn Steele-Moore, Paula Schuman, William Holloway and James D. Neaton

in Clinical Infectious Diseases

Published on behalf of Infectious Diseases Society of America

Volume 33, issue 7, pages 1069-1075
Published in print October 2001 | ISSN: 1058-4838
Published online October 2001 | e-ISSN: 1537-6591 | DOI: http://dx.doi.org/10.1086/322641
Evolution of Antifungal Susceptibility among Candida Species Isolates Recovered from Human Immunodeficiency Virus—Infected Women Receiving Fluconazole Prophylaxis

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The effect of fluconazole on the susceptibility of Candida isolates recovered from women infected with human immunodeficiency virus (HIV) was evaluated in a randomized, double-blind, placebo-controlled trial. Women with CD4+ cell counts of ≤300 cells/mm3 received either fluconazole (200 mg/week) or placebo as prophylaxis. The antifungal susceptibility of specimens was evaluated. One patient who received fluconazole and 2 patients assigned to placebo had Candida albicans isolates recovered that were resistant to fluconazole (MIC, ≥64 µg/mL). Eleven patients assigned fluconazole and 4 patients assigned placebo had non-albicans Candida strains (all Candida glabrata) recovered that were resistant to fluconazole. There was significant azole cross-resistance among the non-albicans Candida species isolates. Although the rate of azole resistance did not significantly increase after fluconazole prophylaxis, there was a trend toward more in vitro azole resistance in C. glabrata isolates from patients assigned fluconazole. Moreover, the majority of resistant vaginal isolates of Candida species were recovered after initiation of open-label fluconazole use.

Journal Article.  3902 words.  Illustrated.

Subjects: Infectious Diseases ; Immunology ; Public Health and Epidemiology ; Microbiology

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