Journal Article

Human Herpesvirus 6 Reactivation and Encephalitis in Allogeneic Bone Marrow Transplant Recipients

D. M. Zerr, T. A. Gooley, L. Yeung, M.-L. Huang, P. Carpenter, J. C. Wade, L. Corey and C. Anasetti

in Clinical Infectious Diseases

Published on behalf of Infectious Diseases Society of America

Volume 33, issue 6, pages 763-771
Published in print September 2001 | ISSN: 1058-4838
Published online September 2001 | e-ISSN: 1537-6591 | DOI: https://dx.doi.org/10.1086/322642
Human Herpesvirus 6 Reactivation and Encephalitis in Allogeneic Bone Marrow Transplant Recipients

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To determine whether receipt of an investigational anti-CD3 monoclonal antibody (BC3) increased the risk of human herpesvirus 6 (HHV-6) reactivation and development of encephalitis in bone marrow transplant (BMT) recipients, persons who had and had not received BC3 were compared. Odds of HHV-6 reactivation were higher among BC3 recipients than among control patients (odds ratio, 2.5; 95% confidence interval [CI], 1.3–4.7). In addition, BC3 recipients were more likely than control patients to develop encephalitis (risk ratio [RR], 3.5; 95% CI, 1.3–9.5), and this association followed a BC3 dose-dependent relationship (P=.03, by Mantel-Haenszel χ2 test). In a multivariable model, HHV-6 reactivation and receipt of BC3 were associated with increased risk of encephalitis (RR, 5.4; 95% CI, 1.9–15.3, and RR, 3.3; 95% CI, 1.2–9.1, respectively). In conclusion, both HHV-6 reactivation and receipt of BC3 for prophylaxis of acute graft-versus-host disease independently increased the risk of encephalitis in allogeneic BMT recipients. Prospective studies to better define the relationship between HHV-6 reactivation and encephalitis in allogeneic BMT recipients are warranted.

Journal Article.  5889 words.  Illustrated.

Subjects: Infectious Diseases ; Immunology ; Public Health and Epidemiology ; Microbiology

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