Journal Article

Polyclonal Proliferation of Large Granular Lymphocytes during Cytomegalovirus Primary Infection in a Human Immunodeficiency Virus—Infected Patient Receiving Antiretroviral Therapy

Andreas Kronenberg, Jörg D. Seebach, Walter Bossart and Rainer Weber

in Clinical Infectious Diseases

Published on behalf of Infectious Diseases Society of America

Volume 33, issue 5, pages e34-e36
Published in print September 2001 | ISSN: 1058-4838
Published online September 2001 | e-ISSN: 1537-6591 | DOI: http://dx.doi.org/10.1086/322652
Polyclonal Proliferation of Large Granular Lymphocytes during Cytomegalovirus Primary Infection in a Human Immunodeficiency Virus—Infected Patient Receiving Antiretroviral Therapy

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We report the first case of a patient infected with HIV in whom polyclonal CD8+/CD57- T lymphocyte large granular lymphocyte (LGL) proliferation was observed in association with cytomegalovirus primary infection. Because the differential diagnosis of an increased number of LGLs includes both monoclonal LGL leukemia and polyclonal proliferation of LGL, patients in whom LGL proliferation is detected always need close hematological and clinical observation to determine whether therapeutic intervention is necessary.

Journal Article.  2034 words.  Illustrated.

Subjects: Infectious Diseases ; Immunology ; Public Health and Epidemiology ; Microbiology

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