Journal Article

Human Immunodeficiency Virus—Seronegative Adults with Extrapulmonary Tuberculosis Have Abnormal Innate Immune Responses

Timothy R. Sterling, Susan E. Dorman, Richard E. Chaisson, Li Ding, Judith Hackman, Kristina Moore and Steven M. Holland

in Clinical Infectious Diseases

Published on behalf of Infectious Diseases Society of America

Volume 33, issue 7, pages 976-982
Published in print October 2001 | ISSN: 1058-4838
Published online October 2001 | e-ISSN: 1537-6591 | DOI: http://dx.doi.org/10.1086/322670
Human Immunodeficiency Virus—Seronegative Adults with Extrapulmonary Tuberculosis Have Abnormal Innate Immune Responses

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Extrapulmonary tuberculosis is presumably a marker of underlying immunodeficiency, but cytokine response pathways in these patients have not been well studied. Cytokine responses of peripheral blood mononuclear cells from human immunodeficiency virus—seronegative adults with prior culture-confirmed extrapulmonary tuberculosis were compared with those of persons with latent Mycobacterium tuberculosis infection. Mitogen-stimulated interferon (IFN)-γ production, interleukin (IL)-12 production, and IFN-γ receptor— and IL-12 receptor—mediated cytokine production did not differ between case patients and control patients. However, median resting IL-8 production was significantly lower in case patients than control patients (8051 vs. 19,290 pg/mL; P = .009). In addition, the median tumor necrosis factor (TNF)—α response was lower in case patients than control patients after stimulation with lipopolysaccharide (833 vs. 1149 pg/mL; P = .06) and lipopolysaccharide plus IFN-γ (3301 vs. 4411 pg/mL; P = .04). These abnormalities in resting IL-8 and lipopolysaccharide-induced TNF-α production were not associated with IFN-γ or IL-12 abnormalities and were detected up to several years after cure of disease, suggesting an abnormality in innate immunity.

Journal Article.  3819 words.  Illustrated.

Subjects: Infectious Diseases ; Immunology ; Public Health and Epidemiology ; Microbiology

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