Journal Article

Penetration of the Nucleoside Analogue Abacavir into the Genital Tract of Men Infected with Human Immunodeficiency Virus Type 1

Rieneke M. E. van Praag, Rolf P. G. van Heeswijk, Suzanne Jurriaans, Joep M. A. Lange, Richard M. W. Hoetelmans and Jan M. Prins

in Clinical Infectious Diseases

Published on behalf of Infectious Diseases Society of America

Volume 33, issue 8, pages e91-e92
Published in print October 2001 | ISSN: 1058-4838
Published online October 2001 | e-ISSN: 1537-6591 | DOI: http://dx.doi.org/10.1086/322682
Penetration of the Nucleoside Analogue Abacavir into the Genital Tract of Men Infected with Human Immunodeficiency Virus Type 1

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The male genital tract is considered an anatomical reservoir during therapy for human immunodeficiency virus infection, because the blood-testis barrier may prevent antiretroviral drugs (e.g., the protease inhibitors ritonavir, saquinavir and nelfinavir) from entering the male genital tract. To our knowledge, there are currently no available data on the penetration of the nucleoside analogue abacavir into the male genital tract. Our report shows that abacavir has good penetration into the male genital tract.

Journal Article.  1303 words.  Illustrated.

Subjects: Infectious Diseases ; Immunology ; Public Health and Epidemiology ; Microbiology

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