Journal Article

Infection with <i>Burkholderia cepacia</i> Complex Genomovars in Patients with Cystic Fibrosis: Virulent Transmissible Strains of Genomovar III Can Replace <i>Burkholderia multivorans</i>

Eshwar Mahenthiralingam, Peter Vandamme, Maureen E. Campbell, Deborah A. Henry, Anna M. Gravelle, Lawrence T. K. Wong, A. George F. Davidson, Pearce G. Wilcox, Barbara Nakielna and David P. Speert

in Clinical Infectious Diseases

Published on behalf of Infectious Diseases Society of America

Volume 33, issue 9, pages 1469-1475
Published in print November 2001 | ISSN: 1058-4838
Published online November 2001 | e-ISSN: 1537-6591 | DOI: http://dx.doi.org/10.1086/322684
Infection with Burkholderia cepacia Complex Genomovars in Patients with Cystic Fibrosis: Virulent Transmissible Strains of Genomovar III Can Replace Burkholderia multivorans

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Infection with Burkholderia cepacia complex in patients with cystic fibrosis (CF) results in highly variable clinical outcomes. The purpose of this study was to determine if there are genomovar-specific disparities in transmission and disease severity. B. cepacia complex was recovered from 62 patients with CF on ⩾1 occasions (genomovar III, 46 patients; genomovar II [B. multivorans], 19 patients; genomovar IV [B. stabilis], 1 patient; genomovar V [B. vietnamiensis], 1 patient; and an unclassified B. cepacia complex strain, 1 patient). Patient-to-patient spread was observed with B. cepacia genomovar III, but not with B. multivorans. Genomovar III strains replaced B. multivorans in 6 patients. Genomovar III strains were also associated with a poor clinical course and high mortality. Infection control practices should be designed with knowledge about B. cepacia complex genomovar status; patients infected with transmissible genomovar III strains should not be cohorted with patients infected with B. multivorans and other B. cepacia genomovars.

Journal Article.  4455 words.  Illustrated.

Subjects: Infectious Diseases ; Immunology ; Public Health and Epidemiology ; Microbiology

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