Journal Article

Cytomegalovirus Ventriculoencephalitis in a Bone Marrow Transplant Recipient Receiving Antiviral Maintenance: Clinical and Molecular Evidence of Drug Resistance

Susan K. Seo, Anne Regan, Tomas Cihlar, Deborah C. Lin, Farid Boulad, Diane George, Vinod K. Prasad, Timothy E. Kiehn and Bruce Polsky

in Clinical Infectious Diseases

Published on behalf of Infectious Diseases Society of America

Volume 33, issue 9, pages e105-e108
Published in print November 2001 | ISSN: 1058-4838
Published online November 2001 | e-ISSN: 1537-6591 | DOI: http://dx.doi.org/10.1086/323022
Cytomegalovirus Ventriculoencephalitis in a Bone Marrow Transplant Recipient Receiving Antiviral Maintenance: Clinical and Molecular Evidence of Drug Resistance

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We describe a case of CMV ventriculoencephalitis in a severely immunocompromised bone marrow transplant recipient who was receiving combination therapy with ganciclovir and foscarnet for treatment of viremia and retinitis. Analysis of sequential viral isolates recovered from the patient's cerebrospinal fluid suggested that disease developed because of the presence of viral resistance and, possibly, low tissue penetration of antiviral agents.

Journal Article.  2587 words.  Illustrated.

Subjects: Infectious Diseases ; Immunology ; Public Health and Epidemiology ; Microbiology

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