Journal Article

Pneumococcal Conjugate Vaccine Serotypes of <i>Streptococcus pneumoniae</i> Isolates and the Antimicrobial Susceptibility of Such Isolates in Children with Otitis Media

Moses L. Joloba, Anne Windau, Saralee Bajaksouzian, Peter C. Appelbaum, William P. Hausdorff and Michael R. Jacobs

in Clinical Infectious Diseases

Published on behalf of Infectious Diseases Society of America

Volume 33, issue 9, pages 1489-1494
Published in print November 2001 | ISSN: 1058-4838
Published online November 2001 | e-ISSN: 1537-6591 | DOI: http://dx.doi.org/10.1086/323027
Pneumococcal Conjugate Vaccine Serotypes of Streptococcus pneumoniae Isolates and the Antimicrobial Susceptibility of Such Isolates in Children with Otitis Media

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The ability of the recently licensed 7-valent pneumococcal conjugate vaccine to cover isolates that cause otitis media, especially drug-resistant ones, was assessed using 500 recently obtained US isolates. Of these isolates, 418 (84%) belonged to vaccine-related serogroups, whereas 82 (16%) belonged to non—vaccine-related serogroups. Serotype 3 accounted for 48 (59%) of the non—vaccine-related serogroups. In addition, 93% of the isolates from patients ⩽3 years of age belonged to serotypes that were included in or related to the heptavalent vaccine, compared with 49% of the isolates from older patients (P = .001). Most of the isolates (98%–100%) that were resistant to the antimicrobial agents tested were covered by the heptavalent vaccine, including 95.1% of the isolates from patients <2 years of age. The 7-valent pneumococcal conjugate vaccine could therefore potentially provide protection against all but 1 (type 3) of the common otitis media—associated pneumococcal serogroups identified in this study as well as against 98% of antibiotic-resistant isolates.

Journal Article.  3499 words.  Illustrated.

Subjects: Infectious Diseases ; Immunology ; Public Health and Epidemiology ; Microbiology

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