Journal Article

Streptococcal Pyrogenic Exotoxin B Enhances Tissue Damage Initiated by Other <i>Streptococcus pyogenes</i> Products

M. Saouda, W. Wu, P. Conran and M. D. P. Boyle

in The Journal of Infectious Diseases

Published on behalf of Infectious Diseases Society of America

Volume 184, issue 6, pages 723-731
Published in print September 2001 | ISSN: 0022-1899
Published online September 2001 | e-ISSN: 1537-6613 | DOI: http://dx.doi.org/10.1086/323083
Streptococcal Pyrogenic Exotoxin B Enhances Tissue Damage Initiated by Other Streptococcus pyogenes Products

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This study compared the pathology and infection pattern of streptococcal pyrogenic exotoxin B–positive (SpeB+) and SpeB-negative (SpeB) isogenic variants of an M1 isolate of Streptococcus pyogenes in a mouse skin air sac model. SpeB+ strains resulted in severe local tissue damage that extended from the epidermis through the subcutaneous layers, whereas isogenic SpeB variants had reduced gross pathology. At the histologic level, differences in necrosis and host responses to each variant were apparent. Injection of purified SpeB alone into a skin air sac failed to induce any significant tissue damage; however, coinjection of the enzyme with either the wild-type or the speB mutant resulted in increased and accelerated tissue necrosis. Surprisingly, coinjection of the enzyme with the spleen-recovered SpeB variant failed to induce a lesion

Journal Article.  6210 words.  Illustrated.

Subjects: Infectious Diseases ; Immunology ; Public Health and Epidemiology ; Microbiology

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