Journal Article

Complement C4 Deficiency and HLA Homozygosity in Patients with Frequent Intraoral Herpes Simplex Virus Type 1 Infections

Mikko Seppänen, Marja-Liisa Lokki, Tuomo Timonen, Maija Lappalainen, Hanna Jarva, Asko Järvinen, Seppo Sarna, Ville Valtonen and Seppo Meri

in Clinical Infectious Diseases

Published on behalf of Infectious Diseases Society of America

Volume 33, issue 9, pages 1604-1607
Published in print November 2001 | ISSN: 1058-4838
Published online November 2001 | e-ISSN: 1537-6591 | DOI: http://dx.doi.org/10.1086/323462
Complement C4 Deficiency and HLA Homozygosity in Patients with Frequent Intraoral Herpes Simplex Virus Type 1 Infections

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Three consecutive patients with no apparent immunodeficiency who had frequent intraoral herpes simplex type 1 recurrences, a rare complication of herpes simplex virus infection, were found to have a total deficiency of either the A or B isotype of the complement component C4 and to be homozygous for the studied HLA antigens. A combination of HLA homozygosity, which may lead to impaired T cell recognition of viral peptides, and deficiency in the classical complement pathway, which can compromise virus neutralization, may predispose to severe and frequent herpes simplex virus infections.

Journal Article.  2338 words.  Illustrated.

Subjects: Infectious Diseases ; Immunology ; Public Health and Epidemiology ; Microbiology

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