Journal Article

Relapse in Persons Treated for Drug-Susceptible Tuberculosis in a Population with High Coinfection with Human Immunodeficiency Virus in New York City

Cynthia R Driver, Sonal S Munsiff, Jiehui Li, Nicole Kundamal and Sukhminder S Osahan

in Clinical Infectious Diseases

Published on behalf of Infectious Diseases Society of America

Volume 33, issue 10, pages 1762-1769
Published in print November 2001 | ISSN: 1058-4838
Published online November 2001 | e-ISSN: 1537-6591 | DOI: http://dx.doi.org/10.1086/323784
Relapse in Persons Treated for Drug-Susceptible Tuberculosis in a Population with High Coinfection with Human Immunodeficiency Virus in New York City

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The optimal duration of tuberculosis treatment for persons infected with human immunodeficiency virus (HIV) has been debated. A cohort of 4571 culture-positive drug-susceptible patients who received ⩾24 weeks of standard 4-drug tuberculosis treatment were assessed to determine the incidence of tuberculosis relapse. Tuberculosis “recurrence” was defined as having a positive culture <30 days after the last treatment date and “relapse” as having a positive culture ⩾30 days after the last treatment. Patients infected with HIV were more likely than those who were uninfected to have recurrence or relapse (2.0 vs. 0.4 per 100 person-years, P < .001). Patients infected with HIV who received ⩽36 weeks of treatment were more likely than those who received >36 weeks to have a recurrence (7.9% vs. 1.4%, P < .001). Clinicians should be aware of the possibility of recurrence of tuberculosis 6–9 months after the start of treatment. Sputum evaluation to ensure cure or assessment 3 months after completion of treatment should be performed among persons infected with HIV who receive the shorter regimen.

Journal Article.  4856 words.  Illustrated.

Subjects: Infectious Diseases ; Immunology ; Public Health and Epidemiology ; Microbiology

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