Journal Article

Risk Factors for <i>Candida tropicalis</i> Fungemia in Patients with Cancer

Dimitrios P. Kontoyiannis, Irfan Vaziri, Hend A. Hanna, Maha Boktour, Jack Thornby, Ray Hachem, Gerald P. Bodey and Issam I. Raad

in Clinical Infectious Diseases

Published on behalf of Infectious Diseases Society of America

Volume 33, issue 10, pages 1676-1681
Published in print November 2001 | ISSN: 1058-4838
Published online November 2001 | e-ISSN: 1537-6591 | DOI: http://dx.doi.org/10.1086/323812
Risk Factors for Candida tropicalis Fungemia in Patients with Cancer

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The risk factors for and presentation of Candida tropicalis fungemia, in comparison with those of Candida albicans, have been incompletely characterized. We compared 43 cases of C. tropicalis fungemia with 148 cases of C. albicans fungemia. In univariate analysis, patients with C. tropicalis fungemia were more likely to have leukemia (P = .0006), prolonged neutropenia (P = .03), and a positive blood culture for more days (P = .02). The 2 groups did not differ with regard to baseline Acute Physiology and Chronic Health Evaluation (APACHE) II score, frequency of catheter-associated fungemia, or response to antifungals. In multivariate analysis, patients with C. tropicalis fungemia were more likely to have leukemia (P = .02), previous neutropenia (P = .002), and a longer stay in the intensive care unit during the infectious episode (P = .01). Also, the response of the breakthrough C. tropicalis fungemia was lower (P = .05). In conclusion, the host determinants associated with susceptibility to C. tropicalis are leukemia and prolonged neutropenia.

Journal Article.  3082 words.  Illustrated.

Subjects: Infectious Diseases ; Immunology ; Public Health and Epidemiology ; Microbiology

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