Journal Article

Symptomatic Elevations of Lactic Acid and Their Response to Treatment Manipulation in Human Immunodeficiency Virus—Infected Persons: A Case Series

Juan Delgado, Marianne Harris, Alicja Tesiorowski and Julio S. G. Montaner

in Clinical Infectious Diseases

Published on behalf of Infectious Diseases Society of America

Volume 33, issue 12, pages 2072-2074
Published in print December 2001 | ISSN: 1058-4838
Published online December 2001 | e-ISSN: 1537-6591 | DOI: http://dx.doi.org/10.1086/323980
Symptomatic Elevations of Lactic Acid and Their Response to Treatment Manipulation in Human Immunodeficiency Virus—Infected Persons: A Case Series

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Symptomatic lactic acidemia was seen in 5 human immunodeficiency virus-positive patients receiving combination therapy that included stavudine and ⩾1 other nucleoside. Peak venous lactic acid levels of 3.1–7.4 mmol/L (normal range, 0.5–2.1 mmol/L) were associated with fatigue and rapid weight loss, whereas withdrawal of antiretrovirals led to normalization of venous lactic acid levels, symptomatic improvement, and weight gain. Resumption of an altered therapeutic regimen, which did not include stavudine but did include other nucleosides in 4 of 5 cases, did not result in recurrence of the syndrome after up to 126 days.

Journal Article.  1275 words.  Illustrated.

Subjects: Infectious Diseases ; Immunology ; Public Health and Epidemiology ; Microbiology

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