Journal Article

Clearance of Human Herpesvirus 8 from Blood and Regression of Leukopenia-Associated Aggressive Classic Kaposi's Sarcoma during Interferon-α Therapy: A Case Report

Paolo Monini, Maria Caterina Sirianni, Marina Franco, Laura Vincenzi, Simone Topino, Delia Goletti, Patrizia Leone, Pasqualina Leone, Chiara Chiozzini, Emanuele Nicastri, Massimo Andreoni, Osvaldo Borduagni, Cecilia Sgadari, Giovanni Rezza, Michael Stürzl and Barbara Ensoli

in Clinical Infectious Diseases

Published on behalf of Infectious Diseases Society of America

Volume 33, issue 10, pages 1782-1785
Published in print November 2001 | ISSN: 1058-4838
Published online November 2001 | e-ISSN: 1537-6591 | DOI: http://dx.doi.org/10.1086/323982
Clearance of Human Herpesvirus 8 from Blood and Regression of Leukopenia-Associated Aggressive Classic Kaposi's Sarcoma during Interferon-α Therapy: A Case Report

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A human immunodeficiency virus—negative woman with severe classic Kaposi's sarcoma, idiopathic leukopenia, and massive spread of human herpesvirus 8 (HHV-8) in circulating cells showed stable disease remission in response to systemic interferon-α treatment that was accompanied by increased CD3+ and CD4+ T cell numbers and complete clearance of HHV-8 from the circulation. These results suggest a direct relationship between HHV-8 clearance from blood and regression of Kaposi's sarcoma and are consistent with the in vitro inhibitory effects of interferon-α on HHV-8 infection.

Journal Article.  1989 words.  Illustrated.

Subjects: Infectious Diseases ; Immunology ; Public Health and Epidemiology ; Microbiology

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