Journal Article

The Impact of Human Immunodeficiency Virus Type 1 on Infectiousness of Tuberculosis: A Meta-Analysis

Mario Cruciani, Marina Malena, Oliviero Bosco, Gatti Giorgio and Giovanni Serpelloni

in Clinical Infectious Diseases

Published on behalf of Infectious Diseases Society of America

Volume 33, issue 11, pages 1922-1930
Published in print December 2001 | ISSN: 1058-4838
Published online December 2001 | e-ISSN: 1537-6591 | DOI: http://dx.doi.org/10.1086/324352
The Impact of Human Immunodeficiency Virus Type 1 on Infectiousness of Tuberculosis: A Meta-Analysis

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To assess if the relative infectiousness of patients with tuberculosis is enhanced by coinfection with human immunodeficiency virus type 1 (HIV-1), data from 6 studies of 1240 health care workers who had contact with tuberculosis patients were analyzed. Overall rates of tuberculin skin test conversion were similar regardless of HIV-1 positivity of tuberculosis patients (odds ratio [OR], 1.04; 95% confidence interval [CI], 0.23–1.84). However, when only 3 studies during nosocomial outbreaks of multidrug-resistant Mycobacterium tuberculosis were analyzed, rates of skin test conversion were higher among contacts of HIV-1—positive index cases (OR, 2.85; 95% CI, 1.85–3.85; P = .0002). A second meta-analysis included data from 11 studies of 10,714 household contacts of tuberculosis patients. Prevalence of both skin test positivity (OR, 0.45; 95% CI, 0.20–1.03) and active disease (OR, 1.17; 95% CI, 0.78–1.56) were similar regardless of HIV-1 positivity of index cases. These data suggest that tuberculosis patients with HIV-1 infection are not intrinsically more infectious to their contacts than are HIV-1—negative tuberculosis patients.

Journal Article.  5232 words.  Illustrated.

Subjects: Infectious Diseases ; Immunology ; Public Health and Epidemiology ; Microbiology

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