Journal Article

Chagasic Meningoencephalitis in a Patient with Acquired Immunodeficiency Syndrome: Diagnosis, Follow-Up, and Genetic Characterization of <i>Trypanosoma cruzi</i>

Eliane Lages-Silva, Luis Eduardo Ramirez, Mario Leon Silva-Vergara and Egler Chiari

in Clinical Infectious Diseases

Published on behalf of Infectious Diseases Society of America

Volume 34, issue 1, pages 118-123
Published in print January 2002 | ISSN: 1058-4838
Published online January 2002 | e-ISSN: 1537-6591 | DOI: http://dx.doi.org/10.1086/324355
Chagasic Meningoencephalitis in a Patient with Acquired Immunodeficiency Syndrome: Diagnosis, Follow-Up, and Genetic Characterization of Trypanosoma cruzi

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Early diagnosis of the clinical reactivation of Chagas' disease in human immunodeficiency virus– and Trypanosoma cruzi–coinfected persons is fundamental for a good prognosis. Polymerase chain reaction rapidly and efficiently demonstrated the presence and elimination of T. cruzi in the cerebrospinal fluid of a patient with chagasic meningoencephalitis. Characterization of T. cruzi, directly and indirectly in blood and cerebrospinal fluid samples, demonstrated homogeneity of kinetoplast DNA and the presence of lineage 1 (T. cruzi II) in both parasite populations.

Journal Article.  4424 words.  Illustrated.

Subjects: Infectious Diseases ; Immunology ; Public Health and Epidemiology ; Microbiology

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